\u3000\u3000\u4ece\u9aa8\u79d1\u533b\u751f\u5230\u8bfa\u8d1d\u5c14\u5956
\n\u3000\u3000\u2014\u2014\u5c71\u4e2d\u4f38\u5f25\u53d1\u73b0iPS\u7684\u7814\u7a76\u5386\u7a0b<\/p>\n
\u3000\u3000\u4f5c\u8005\uff1atoptip<\/p>\n
\u3000\u3000\u5f15\u8a00<\/p>\n
\u3000\u3000\u5c71\u4e2d\u4f38\u5f25\uff08Shinya Yamanaka\uff09\u83b7\u5f97\u8bfa\u5956\u5df2\u7ecf\u6709\u51e0\u5929\u4e86\uff0c\u867d\u7136\u4e24\u5e74\u524d\u5728\u542c\u5b8c
\n\u4ed6\u7684\u8bb2\u5ea7\u540e\u6211\u5174\u81f4\u5f88\u9ad8\u5730\u5199\u4e86\u4e24\u7bc7\u535a\u5ba2\uff0c\u8fd9\u4e9b\u5929\u6211\u5374\u6ca1\u6709\u591a\u5c11\u52a8\u529b\u518d\u5199\u4e00\u7bc7\u5b8c\u6574
\n\u7684\u6587\u7ae0\u6765\u4ecb\u7ecd\u4ed6\u7684\u5de5\u4f5c\u3002<\/p>\n
\u3000\u3000\u6211\u4e00\u76f4\u5bf9\u4e2d\u56fd\u73b0\u5728\u8fd8\u76db\u884c\u7684\u89c4\u5212\u6027\u79d1\u7814\uff0c\u5e94\u7528\u5bfc\u5411\u578b\u79d1\u7814\u803f\u803f\u4e8e\u6000\u3002\u8fd9\u4e9b\u6240
\n\u8c13\u7684\u91cd\u5927\u9879\u76ee\u5728\u7acb\u9879\u7684\u5f53\u521d\u5bf9\u76ee\u6807\/\u524d\u666f\u5199\u5f97\u5b8f\u5927\u65e0\u6bd4\uff0c\u4e4b\u540e\u5374\u901a\u5e38\u8349\u8349\u6536\u573a\u3002
\n\u5982\u679c\u90a3\u4e9b\u91cd\u5927\u9879\u76ee\u771f\u7684\u80fd\u5b9e\u73b0\u7acb\u9879\u5f53\u521d\u7684\u7528\u610f\uff0c\u90a3\u8bfa\u8d1d\u5c14\u5956\u65e9\u5c31\u5728\u4e2d\u56fd\u904d\u5730\u5f00\u82b1
\n\u4e86\u3002\u5e7f\u5927\u79d1\u7814\u4eba\u5458\u90fd\u89c9\u5f97\u8fd9\u79cd\u8fd0\u884c\u6a21\u5f0f\u662f\u4e00\u4e2a\u7b11\u8bdd\uff0c\u9976\u6bc5\u3001\u65bd\u4e00\u516c\u7b49\u5927\u725b\u4e5f\u91cd\u70ae
\n\u8f70\u51fb\uff0c\u4f46\u662f\u5206\u94b1\u6e38\u620f\u8fd8\u5728\u8fdb\u884c\u7740\u3002\u800c\u516c\u4f17\uff0c\u5305\u62ec\u76f8\u5f53\u4e00\u90e8\u5206\u79d1\u7814\u4eba\u5458\u4e5f\u5e76\u4e0d\u4e86\u89e3
\n\u79d1\u7814\u7684\u81ea\u8eab\u89c4\u5f8b\uff0c\u603b\u662f\u4e00\u518d\u5730\u95ee\u505a\u57fa\u7840\u7814\u7a76\u6709\u4ec0\u4e48\u7528\u3002<\/p>\n
\u3000\u3000Shinya Yamanaka\u7684\u6210\u529f\u662f\u5178\u578b\u7684\u5c0f\u5b9e\u9a8c\u5ba4\u81ea\u7531\u63a2\u7d22\u7684\u6210\u529f\u3002\u4ed6\u7684\u6210\u529f\u518d\u4e00
\n\u6b21\u63d0\u793a\uff0c\u6709\u76f8\u5f53\u591a\u7684\u79d1\u5b66\u7a81\u7834\u662f\u4e0d\u53ef\u9884\u6d4b\u7684\u3002\u5982\u679c\u4e2d\u56fd\u6709\u5927\u6279\u4f18\u8d28\u7684\u5c0f\u5b9e\u9a8c\u5ba4\u5f97
\n\u5230\u7a33\u5b9a\u7684\u8d44\u52a9\uff0c\u90a3\u4e48\u7c7b\u4f3c\u7684\u79d1\u5b66\u7a81\u7834\u5c31\u4f1a\u968f\u673a\u4f46\u662f\u5fc5\u7136\u5730\u4ea7\u751f\u3002\u4ece\u8fd9\u79cd\u610f\u4e49\u4e0a\u8bb2\uff0c
\n\u5c55\u793aShinya Yamanaka\u5728\u7814\u7a76\u8fc7\u7a0b\u4e2d\u7684\u8fd9\u79cd\u968f\u673a\u6027\u548c\u5fc5\u7136\u6027\uff0c\u5411\u516c\u4f17\u79d1\u666e\u79d1\u7814\u6d3b
\n\u52a8\u662f\u5982\u4f55\u8fdb\u884c\u7684\uff0c\u662f\u503c\u5f97\u6211\u82b1\u4e00\u70b9\u65f6\u95f4\u7684\u3002<\/p>\n
\u3000\u3000\u89e3\u6790Shinya Yamanaka\u53d1\u73b0\u8bf1\u5bfc\u5e72\u7ec6\u80de\uff08iPS\uff09\u7684\u6765\u9f99\u53bb\u8109\u6bd4\u8f83\u7b80\u5355\uff0c\u5c31\u662f\u8ddf
\n\u8e2a\u4ed6\u987a\u6b21\u7814\u7a76\u7684\u57fa\u56e0\uff1aApoBEC1-Nat1-Fbx15\uff0c\u6700\u540e\u53d1\u73b0iPS\u3002\u6709\u8da3\u7684\u662f\u4ed6\u5728\u987a\u6b21
\n\u7814\u7a76\u8fd9\u4e9b\u57fa\u56e0\u7684\u65f6\u5019\u8f6c\u4e86\u4e24\u6b21\u65b9\u5411\uff1aApoB\u662f\u8840\u8102\u86cb\u767d\uff0c\u7814\u7a76\u5b83\u7684\u7f16\u8f91\u9176ApoBEC1
\n\u662f\u4e3a\u4e86\u8c03\u8282\u8840\u8102\uff0c\u4f46\u662f\u5374\u610f\u5916\u53d1\u73b0\u8fc7\u8868\u8fbeApoBEC1\u7684\u5c0f\u9f20\u5f97\u4e86\u809d\u764c\uff1b\u4e3a\u4e86\u7814\u7a76\u81f4
\n\u764c\u673a\u7406\uff0cShinya\u627e\u5230ApoBEC1\u7684\u4e0b\u6e38\u86cb\u767dNat1\uff0cNat1\u7684\u6572\u9664\u5bfc\u81f4\u5c0f\u9f20\u5728\u80da\u80ce\u671f\u6b7b
\n\u4ea1\uff0c\u4ee5\u53ca\u80da\u80ce\u5e72\u7ec6\u80de\u5728\u4f53\u5916\u65e0\u6cd5\u5206\u5316\uff1b\u4e8e\u662f\u4ed6\u53c8\u5f00\u59cb\u7814\u7a76\u8d77\u80da\u80ce\u5e72\u7ec6\u80de\uff0c\u627e\u5230\u8bb8
\n\u591a\u80da\u80ce\u5e72\u7ec6\u80de\u7279\u5f02\u8868\u8fbe\u7684\u57fa\u56e0\uff0c\u5176\u4e2d\u4e4b\u4e00\u662fFbx15\uff0c\u6700\u540e\u7528Fbx15\u6572\u9664\u9f20\u5efa\u7acb
\nassay\uff08\u7b5b\u9009\u65b9\u6cd5\/\u7cfb\u7edf\uff09\uff0c\u5e78\u8fd0\u5730\u7b5b\u9009\u51fa\u4e86iPS\u3002<\/p>\n
\u3000\u3000\u4ece\u9aa8\u79d1\u5916\u79d1\u5230\u535a\u58eb\u9636\u6bb5<\/p>\n
\u3000\u3000Shinya Yamanka\u5ff5\u9ad8\u4e2d\u65f6\u8ff7\u4e0a\u67d4\u9053\uff0c\u56e0\u4e3a\u53d7\u4f24\u7ecf\u5e38\u4e0a\u533b\u9662\uff0c\u4ed6\u5728\u7238\u7238\u7684\u5efa\u8bae
\n\u4e0b\u968f\u540e\u8003\u5165\u56fd\u7acb\u795e\u6237\u5927\u5b66\u533b\u5b66\u90e8\uff0c\u51c6\u5907\u4ee5\u540e\u505a\u4e00\u540d\u9aa8\u79d1\u5916\u79d1\u533b\u751f\u3002\u5927\u5b66\u6bd5\u4e1a\u505a\u4e34
\n\u5e8a\u5b9e\u4e60\u671f\u95f4\uff0c\u4ed6\u53d1\u73b0\u81ea\u5df1\u5bf9\u624b\u672f\u5176\u5b9e\u6ca1\u6709\u4ec0\u4e48\u5929\u5206\uff0c\u522b\u4eba\u505a20\u5206\u949f\u7684\u624b\u672f\u4ed6\u4e24\u4e2a
\n\u5c0f\u65f6\u4e5f\u672a\u5fc5\u5b8c\u6210\uff1b\u5e76\u4e14\u4ed6\u89c9\u5f97\u505a\u533b\u751f\u518d\u4f18\u79c0\u4e5f\u53ea\u80fd\u5e2e\u52a9\u5c11\u6570\u7684\u75c5\u4eba\uff0c\u800c\u533b\u5b66\u7814\u7a76
\n\u6709\u6210\u679c\u7684\u8bdd\u901a\u5e38\u53ef\u4ee5\u5e2e\u52a9\u66f4\u591a\u7684\u75c5\u4eba\uff0c\u6240\u4ee5\u4ed6\u7684\u5174\u8da3\u8f6c\u5411\u57fa\u7840\u533b\u5b66\u7814\u7a76\u3002\u5728\u5927\u962a
\n\u5e02\u7acb\u5927\u5b66\u535a\u58eb\u671f\u95f4\uff0cShinya\u7684\u4e3b\u8981\u5de5\u4f5c\u662f\u7814\u7a76\u8840\u538b\u8c03\u8282\u7684\u5206\u5b50\u673a\u7406[1, 2]\u3002\u5728\u7814
\n\u7a76\u8fc7\u7a0b\u4e2d\uff0cShinya\u5bf9\u5c0f\u9f20\u8f6c\u57fa\u56e0\u548c\u57fa\u56e0\u6572\u9664\u6280\u672f\u611f\u5230\u9707\u60ca\uff0c\u4e8e\u662f\u4ed6\u5728\u7533\u8bf7\u535a\u58eb\u540e
\n\u4f4d\u7f6e\u7684\u65f6\u5019\u8054\u7cfb\u7684\u90fd\u662f\u5229\u7528\u8fd9\u4e9b\u6280\u672f\u7684\u5b9e\u9a8c\u5ba4\u3002<\/p>\n
\u3000\u3000\u535a\u58eb\u540e\u9636\u6bb5-ApoBEC1<\/p>\n
\u3000\u30001993\u5e74\uff0c\u8fd9\u4f4d\u5931\u8d25\u7684\u9aa8\u79d1\u533b\u751f\u6700\u540e\u88ab\u52a0\u5ddeGladstone Institutes\u7684Thomas
\nInnerarity\u7eb3\u5165\u95e8\u4e0b\u3002Thomas\u5b9e\u9a8c\u5ba4\u7814\u7a76\u7684\u662f\u8840\u8102\u8c03\u8282\uff0c\u8ddfShinya\u535a\u58eb\u671f\u95f4\u7684\u5de5
\n\u4f5c\u6709\u70b9\u5173\u7cfb\u3002Shinya\u7684\u65b0\u8bfe\u9898\u662f\u7814\u7a76ApoB mRNA\u7684\u7f16\u8f91\u86cb\u767dApoBEC1\u3002<\/p>\n
\u3000\u3000ApoB\u662f\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u7684\u4e3b\u8981\u6784\u6210\u6210\u5206\u3002ApoB mRNA\u53ef\u4ee5\u88ab\u7f16\u8f91\u9176ApoBEC1\u8131\u6c28
\n\u63d0\u524d\u7ec8\u6b62\u7ffb\u8bd1\uff0c\u5f62\u6210\u4e24\u79cd\u4e0d\u540c\u5927\u5c0f\u7684\u86cb\u767d\uff1a\u5168\u957f\u7684ApoB100\u548c\u5927\u7ea6\u4e00\u534a\u957f\u7684
\nApoB48\u3002\u7ecf\u7f16\u8f91\u540e\u7684ApoB48\u5728\u8840\u6d46\u4e2d\u4f1a\u88ab\u8fc5\u901f\u6e05\u9664\u3002Thomas\u9884\u6d4b\uff0c\u5728\u809d\u810f\u4e2d\u8fc7\u8868
\n\u8fbeApoBEC1\uff0c\u8840\u8102\u53ef\u80fd\u964d\u4f4e\uff1b\u5982\u679c\u8fd9\u4e2a\u6a21\u578b\u53ef\u884c\u7684\u8bdd\uff0c\u4e5f\u8bb8\u672a\u6765\u901a\u8fc7\u57fa\u56e0\u7597\u6cd5\u53ef
\n\u4ee5\u5e2e\u52a9\u4e00\u4e9b\u80a5\u80d6\u75c5\u4eba\u964d\u4f4e\u8840\u8102\u3002<\/p>\n
\u3000\u3000Shinya\u4e00\u5468\u4e03\u5929\u5730\u52e4\u594b\u5de5\u4f5c\uff0c\u82b1\u4e86\u516d\u4e2a\u6708\u505a\u6210\u4e86\u8f6c\u57fa\u56e0\u9f20\u3002\u6709\u4e00\u5929\u65e9\u4e0a\uff0c\u5e2e
\n\u4ed6\u7ef4\u62a4\u5c0f\u9f20\u7684\u6280\u672f\u5458\u544a\u8bc9\u4ed6\uff1aShinya\uff0c\u4f60\u7684\u8bb8\u591a\u5c0f\u9f20\u90fd\u6000\u5b55\u4e86\uff0c\u53ef\u662f\u5b83\u4eec\u662f\u516c\u7684\u3002
\nShinya\u8bf4\u4f60\u4e0d\u662f\u8ddf\u6211\u5f00\u73a9\u7b11\u5427\u3002\u4ed6\u5230\u8001\u9f20\u623f\u4e00\u770b\uff0c\u679c\u771f\u6709\u5f88\u591a\u516c\u9f20\u770b\u8d77\u6765\u6000\u5b55\u4e86\u3002
\n\u4ed6\u89e3\u5256\u4e86\u5176\u4e2d\u51e0\u53ea\uff0c\u53d1\u73b0\u539f\u6765\u662f\u5c0f\u9f20\u5f97\u4e86\u809d\u764c\uff0c\u809d\u810f\u80bf\u5927\u6491\u5927\u4e86\u809a\u76ae\u3002<\/p>\n
\u3000\u3000ApoBEC1\u8fc7\u8868\u8fbe\u540e\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u662f\u964d\u4f4e\u4e86\uff0c\u4f46\u662f\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\u5374\u5347\u9ad8\u4e86\uff0c\u540c
\n\u65f6\u8fd8\u5f97\u4e86\u809d\u764c\uff0c\u8fd9\u4e70\u5356\u4e0d\u5408\u7b97\u554a[3]\u3002Shinya\u5728\u4e00\u6b21\u8bb2\u5ea7\u4e2d\u603b\u7ed3\u4e86\u5176\u4e2d\u7684\u7ecf\u9a8c\u6559
\n\u8bad\uff1a\u5176\u4e00\uff0c\u79d1\u5b66\u662f\u4e0d\u53ef\u9884\u6d4b\u7684\uff1b\u5176\u4e8c\uff0c\u4e0d\u8981\u5c1d\u8bd5\u5728\u75c5\u4eba\u8eab\u4e0a\u505a\u65b0\u57fa\u56e0\u7684\u6cbb\u7597\uff1b\u5176
\n\u4e09\uff0c\u4e5f\u8bb8\u6700\u91cd\u8981\u7684\u662f\uff0c\u4e0d\u8981\u76f8\u4fe1\u5bfc\u5e08\u7684\u5047\u8bf4\u3002<\/p>\n
\u3000\u3000Thomas\u5bf9\u7ed3\u679c\u4e0d\u80fd\u7b26\u5408\u9884\u671f\u5f88\u5931\u671b\uff0c\u4f46\u662f\u8fd9\u4e2a\u9884\u60f3\u4e4b\u5916\u7684\u7ed3\u679c\u5374\u52fe\u8d77\u4e86
\nShinya\u7684\u597d\u5947\u5fc3\uff1a\u7a76\u7adf\u662f\u4ec0\u4e48\u673a\u7406\u4f7f\u5c0f\u9f20\u5f97\u80bf\u7624\u7684\u5462\uff1f\u597d\u5728Thomas\u8db3\u591f\u5f00\u660e\uff0c\u4ed6
\n\u5141\u8bb8Shinya\u504f\u79bb\u5b9e\u9a8c\u5ba4\u7684\u4e3b\u653b\u65b9\u5411\uff0c\u7ee7\u7eed\u63a2\u7d22ApoBEC1\u7684\u81f4\u764c\u673a\u7406\u3002\u53ef\u4ee5\u60f3\u89c1\uff0c
\nApoBEC1\u8fc7\u8868\u8fbe\u4ee5\u540e\u4e5f\u53ef\u80fd\u4f1a\u7f16\u8f91ApoB\u4e4b\u5916\u7684\u5176\u5b83mRNA\uff0c\u627e\u5230\u8fd9\u4e9bmRNA\u4e5f\u8bb8\u53ef\u4ee5
\n\u89e3\u91caApoBEC1\u4e3a\u4ec0\u4e48\u80fd\u81f4\u764c\u3002<\/p>\n
\u3000\u3000\u7531\u4e8e\u5df2\u77e5ApoBEC1\u9700\u8bc6\u522b\u5e95\u7269mRNA\u7684\u7279\u5f02\u5e8f\u5217\u624d\u80fd\u7f16\u8f91\uff0cShinya\u636e\u6b64\u8bbe\u8ba1\u5f15
\n\u7269\u6269\u589e\uff0c\u627e\u5230\u4e86ApoBEC1\u7684\u4e00\u4e2a\u65b0\u5e95\u7269-\u6291\u5236\u86cb\u767d\u7ffb\u8bd1\u7684\u57fa\u56e0Nat1\u3002ApoBEC1\u8fc7\u8868
\n\u8fbe\u540e\uff0cNat1\u86cb\u767d\u6d88\u5931[4]\u3002\u4ece\u903b\u8f91\u4e0a\u8bb2\uff0c\u5982\u679cNat1\u662f\u5bfc\u81f4ApoBEC1\u81f4\u764c\u7684\u91cd\u8981\u5206\u5b50\uff0c
\n\u90a3\u4e48Nat1\u6572\u9664\u7684\u5c0f\u9f20\u4e5f\u4f1a\u957f\u764c\u3002<\/p>\n
\u3000\u3000\u57fa\u56e0\u6572\u9664\u6bd4\u8d77\u8f6c\u57fa\u56e0\u8981\u66f4\u52a0\u590d\u6742\uff0c\u9700\u8981\u628a\u6784\u5efa\u7684\u8d28\u7c92\u539f\u4f4d\u6574\u5408\u5230\u4f53\u5916\u57f9\u517b\u7684
\n\u80da\u80ce\u5e72\u7ec6\u80de\u4e2d\u3002\u57fa\u56e0\u6572\u9664\u6280\u672f\u4e0d\u5c31\u662fShinya\u535a\u58eb\u9636\u6bb5\u505a\u68a6\u90fd\u60f3\u5b66\u7684\u6280\u672f\u5417\uff1f\u4e8e\u662f
\nShinya\u627e\u5230\u6240\u91cc\u505a\u57fa\u56e0\u6572\u9664\u7684\u4e13\u5bb6\uff0c\u5f53\u65f6\u8fd8\u662f\u52a9\u7406\u6559\u6388\u7684Robert Farese\uff0c\u4ece\u4ed6
\n\u7684\u52a9\u624bHeather Myers\u90a3\u91cc\u5b66\u4e86\u8fd9\u9879\u6280\u672f\u7684\u6bcf\u4e2a\u7ec6\u8282\uff0c\u5e76\u6210\u529f\u5730\u83b7\u5f97\u4e86Nat1\u6572\u9664
\n\u7684\u6742\u5408\u9f20\u3002Heather Myers\u662fShinya\u7684\u7ec8\u751f\u597d\u53cb\uff1bShinya\u53d1\u73b0iPS\u4ee5\u540e\uff0c\u4e5f\u516c\u5f00\u8868
\n\u8fbe\u4e86\u5bf9Heather Myers\u7684\u611f\u6fc0\uff0c\u56e0\u4e3a\u662f\u5979\u544a\u8bc9Shinya\uff0c\u80da\u80ce\u5e72\u7ec6\u80de\u4e0d\u4ec5\u4ec5\u662f\u505a\u6572
\n\u9664\u5c0f\u9f20\u7684\u624b\u6bb5\uff0c\u5176\u672c\u8eab\u4e5f\u53ef\u4ee5\u662f\u975e\u5e38\u6709\u8da3\u7684\u7814\u7a76\u5bf9\u8c61\u3002
\n\u3000\u3000\u5728Shinya\u5174\u81f4\u52c3\u52c3\u5730\u7ee7\u7eed\u8ffd\u95eeNat1\u7684\u529f\u80fd\u65f6\uff0c\u4ed6\u7684\u59bb\u5b50\u5e26\u7740\u5973\u513f\u79bb\u5f00\u4ed6\u56de\u5230
\n\u4e86\u65e5\u672c\u3002\u534a\u5e74\u540e\u4ed6\u51b3\u5b9a\u4e2d\u65ad\u7814\u7a76\u5e26\u7740\u4e09\u53ea\u73cd\u8d35\u7684Nat1\u6742\u5408\u9f20\uff0c\u4e5f\u8ddf\u968f\u5bb6\u4eba\u56de\u56fd\u3002<\/p>\n
\u3000\u3000\u5927\u962a\u7684\u6bdb\u6bdb\u866b\u9636\u6bb5-Nat1<\/p>\n
\u3000\u3000\u51ed\u501f\u4ed6\u5728\u535a\u58eb\u540e\u671f\u95f4\u53d1\u8868\u7684\u56db\u7bc7\u9ad8\u8d28\u91cf\u7684\u4e00\u4f5c\u8bba\u6587\uff0c1996\u5e74Shinya\u5728\u6bcd\u6821\u5927
\n\u962a\u5e02\u7acb\u5927\u5b66\u627e\u5230\u4e86\u52a9\u7406\u6559\u6388\u7684\u804c\u4f4d\uff0c\u7ee7\u7eed\u4ed6\u7684Nat1\u7814\u7a76\u3002<\/p>\n
\u3000\u3000\u518d\u4e00\u6b21\u5730\u4e0e\u9884\u6d4b\u51fa\u73b0\u504f\u5dee\uff1aNat1\u6572\u9664\u540e\uff0c\u7eaf\u5408\u5b50\u5c0f\u9f20\u5728\u80da\u80ce\u53d1\u80b2\u65e9\u671f\u5c31\u6b7b\u4e86\uff0c
\n\u6839\u672c\u65e0\u6cd5\u89c2\u5bdf\u5230\u6210\u9f20\u662f\u5426\u5f97\u80bf\u7624\u3002Shinya\u8fdb\u4e00\u6b65\u7814\u7a76\u53d1\u73b0\uff0c\u6572\u9664Nat1\u7684\u80da\u80ce\u5e72\u7ec6
\n\u80de\u5728\u4f53\u5916\u4e0d\u80fd\u50cf\u6b63\u5e38\u5e72\u7ec6\u80de\u4e00\u6837\u5206\u5316[5]\u3002\u6b64\u65f6\u4ed6\u60f3\u8d77\u4e86Heather Myers\u7684\u8bdd\uff1a\u80da
\n\u80ce\u5e72\u7ec6\u80de\u4e0d\u4ec5\u662f\u5de5\u5177\uff0c\u5b83\u672c\u8eab\u4e5f\u53ef\u4ee5\u662f\u975e\u5e38\u6709\u8da3\u7684\u7814\u7a76\u5bf9\u8c61\u3002\u4ed6\u7684\u5173\u6ce8\u70b9\u5f00\u59cb\u8f6c
\n\u79fb\u5230\u80da\u80ce\u5e72\u7ec6\u80de\u4e0a\u6765\u3002<\/p>\n
\u3000\u3000\u5728\u521a\u56de\u5927\u962a\u7684\u5934\u51e0\u5e74\uff0cShinya\u7531\u4e8e\u521a\u8d77\u6b65\uff0c\u53ea\u80fd\u5f97\u5230\u5c11\u91cf\u7684\u57fa\u91d1\u8d44\u52a9\uff0c\u4ed6\u4e0d
\n\u5f97\u4e0d\u81ea\u5df1\u4e00\u4e2a\u4eba\u517b\u51e0\u767e\u53ea\u5c0f\u9f20\uff0c\u65e5\u5b50\u8fc7\u5f97\u975e\u5e38\u8270\u82e6\u3002\u540c\u65f6\u5927\u962a\u5e02\u7acb\u5927\u5b66\u533b\u5b66\u9662\u7684
\n\u57fa\u7840\u7814\u7a76\u5f88\u8584\u5f31\uff0c\u5468\u56f4\u7684\u4eba\u4e0d\u7406\u89e3Shinya\u7814\u7a76Nat1\u5728\u80da\u80ce\u5e72\u7ec6\u80de\u4e2d\u7684\u529f\u80fd\u6709\u4ec0\u4e48
\n\u610f\u4e49\uff0c\u603b\u662f\u529d\u8bf4\u4ed6\u505a\u4e00\u4e9b\u66f4\u9760\u8fd1\u533b\u836f\u4e34\u5e8a\u65b9\u9762\u7684\u7814\u7a76\u3002\u800cNat1\u7684\u7814\u7a76\u8bba\u6587\u63d0\u4ea4\u7ed9
\n\u6742\u5fd7\u540e\u4e00\u76f4\u88ab\u636e\u7a3f\u3002\u79cd\u79cd\u538b\u529b\u4e0e\u4e0d\u5f97\u5fd7\uff0cShinya\u56e0\u4e4b\u5f97\u4e86\u4e00\u79cd\u75c5\u53ebPAD\uff08Post
\nAmerica Depression\uff0c\u79bb\u5f00\u7f8e\u56fd\u540e\u7684\u6291\u90c1\u75c7\uff1b\u81ea\u521b\u7684\u73a9\u7b11\u8bdd\uff09\uff0c\u51e0\u4e4e\u8981\u653e\u5f03\u79d1\u7814
\n\u56de\u9505\u505a\u9aa8\u79d1\u533b\u751f\u3002<\/p>\n
\u3000\u3000\u5728\u4ed6\u6700\u4f4e\u8c37\u7684\u65f6\u5019\uff0c\u6709\u4e24\u4ef6\u4e8b\u60c5\u628a\u4ed6\u4ecePAD\u4e2d\u633d\u6551\u4e86\u56de\u6765\u3002\u5176\u4e00\u662fJames
\nThomson\uff08\u4fde\u541b\u82f1\u7684\u5bfc\u5e08\uff0c2007\u5e74\u51e0\u4e4e\u4e0eShinya\u540c\u65f6\u5ba3\u5e03\u505a\u51fa\u4e86\u4eba\u7684iPS\uff09\u57281998
\n\u5e74\u5ba3\u5e03\u4ece\u4eba\u7684\u56ca\u80da\u4e2d\u91c7\u96c6\u5e76\u5efa\u7acb\u4e86\u80da\u80ce\u5e72\u7ec6\u80de\u7cfb\uff0c\u8fd9\u4e9b\u5e72\u7ec6\u80de\u5728\u4f53\u5916\u57f9\u517b\u51e0\u4e2a\u6708
\n\u540e\u8fd8\u53ef\u4ee5\u5206\u5316\u6210\u4e0d\u540c\u80da\u5c42\u7684\u7ec6\u80de\uff0c\u6bd4\u5982\u80a0\u4e0a\u76ae\u7ec6\u80de\uff0c\u8f6f\u9aa8\u7ec6\u80de\uff0c\u795e\u7ecf\u4e0a\u76ae\u7ec6\u80de\u7b49
\n[6]\u3002\u8fd9\u7ed9\u4e86Shinya\u5de8\u5927\u7684\u9f13\u821e\uff0c\u4ed6\u5f00\u59cb\u66f4\u52a0\u575a\u4fe1\u80da\u80ce\u5e72\u7ec6\u80de\u7814\u7a76\u662f\u6709\u610f\u4e49\u7684\uff0c
\n\u5c06\u6765\u5fc5\u7136\u6709\u4e00\u5929\u4f1a\u7528\u4e8e\u4e34\u5e8a\u3002\u7b2c\u4e8c\u4ef6\u4e8b\u662f\u6761\u4ef6\u66f4\u52a0\u4f18\u8d8a\u7684\u5948\u826f\u5148\u7aef\u79d1\u5b66\u6280\u672f\u7814\u7a76
\n\u751f\u9662\u770b\u4e0a\u4e86\u4ed6\u7684\u7279\u957f\uff0c\u62db\u8058\u4ed6\u53bb\u5efa\u7acb\u4e00\u4e2a\u505a\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\u7684facility\uff08\u4e2d\u5fc3\uff1f\u8bbe
\n\u65bd\uff1f\uff09\uff0c\u5e76\u7ed9\u4ed6\u63d0\u4f9b\u4e86\u526f\u6559\u6388\u7684\u804c\u4f4d\u3002<\/p>\n
\u3000\u3000\u5948\u826f\u7684\u6210\u86f9\u9636\u6bb5-Fbx15<\/p>\n
\u3000\u3000\u5343\u8f9b\u4e07\u82e6\u8131\u4e86\u51e0\u5c42\u76ae\u540e\uff0cShinya\u7ec8\u4e8e\u62e5\u6709\u4e86\u81ea\u5df1\u72ec\u7acb\u7684\u5b9e\u9a8c\u5ba4\u3002\u7b2c\u4e00\u6b21\u53ef\u4ee5
\n\u62db\u5e2e\u624b\uff0c\u597d\u723d\u554a\u3002\u4f46\u662f\u95ee\u9898\u53c8\u6765\u4e86\uff1a\u7814\u7a76\u751f\u7684\u751f\u6e90\u662f\u6709\u9650\u7684\uff0c\u5b66\u751f\u4f1a\u503e\u5411\u4e8e\u9009\u62e9
\n\u8d44\u5386\u66f4\u8001\u6761\u4ef6\u66f4\u597d\u7684\u5b9e\u9a8c\u5ba4\uff0c\u800c\u4e0d\u4e00\u5b9a\u4f1a\u9009\u62e9\u521a\u8d77\u6b65\u7684\u5b9e\u9a8c\u5ba4\u3002\u4e3a\u4e86\u5438\u5f15\u5b66\u751f\u5230
\n\u4ed6\u5b9e\u9a8c\u5ba4\uff0cShinya\u51a5\u601d\u82e6\u60f3\u4e86\u597d\u4e00\u9635\uff0c\u63d0\u51fa\u4e86\u4e00\u4e2a\u96c4\u5fc3\u52c3\u52c3\u7684\u8ba1\u5212\uff0c\u58f0\u79f0\u5b9e\u9a8c\u5ba4
\n\u7684\u8fdc\u666f\u76ee\u6807\u662f\u7814\u7a76\u600e\u4e48\u4ece\u7ec8\u672b\u5206\u5316\u7684\u6210\u4f53\u7ec6\u80de\u53d8\u56de\u591a\u80fd\u7684\u5e72\u7ec6\u80de\u3002<\/p>\n
\u3000\u3000\u5f53\u65f6\u79d1\u5b66\u754c\u7684\u4e3b\u6d41\u662f\u7814\u7a76\u600e\u4e48\u628a\u80da\u80ce\u591a\u80fd\u5e72\u7ec6\u80de\u5206\u5316\u6210\u5404\u79cd\u4e0d\u540c\u7ec4\u7ec7\u7684\u7ec6\u80de\uff0c
\n\u4ee5\u671f\u7528\u8fd9\u4e9b\u5206\u5316\u7684\u529f\u80fd\u7ec6\u80de\u53d6\u4ee3\u53d7\u635f\u7684\u6216\u8005\u6709\u75be\u75c5\u7684\u7ec4\u7ec7\u7ec6\u80de\u3002Shinya\u8ba4\u4e3a\u81ea\u5df1
\n\u7684\u5b9e\u9a8c\u5ba4\u6ca1\u6709\u5b9e\u529b\u8ddf\u8fd9\u4e9b\u5927\u725b\u7ade\u4e89\uff0c\u90a3\u4e0d\u5982\u53cd\u5176\u9053\u800c\u884c\u4e4b\uff0c\u7814\u7a76\u600e\u4e48\u4ece\u5206\u5316\u7684\u7ec6
\n\u80de\u9006\u8f6c\u4e3a\u591a\u80fd\u5e72\u7ec6\u80de\u3002<\/p>\n
\u3000\u3000\u5f53\u65f6\u79d1\u5b66\u754c\u7684\u4e3b\u6d41\u89c2\u70b9\u8ba4\u4e3a\uff0c\u54fa\u4e73\u52a8\u7269\u80da\u80ce\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u7684\u7ec6\u80de\u5206\u5316\u662f\u5355\u5411\u7684\uff0c
\n\u5c31\u50cf\u662f\u65f6\u95f4\u4e0d\u53ef\u9006\u8f6c\u3002\u8fd9\u4e2a\u89c2\u70b9\u4e5f\u5e76\u975e\u6ca1\u6709\u7834\u7efd\uff0c\u6bd4\u5982\u690d\u7269\u7ec4\u7ec7\u5c31\u5177\u6709\u591a\u80fd\u6027\uff1a
\n\u4e00\u4e9b\u690d\u7269\u7684\u830e\u63d2\u5165\u571f\u58e4\u4f1a\u91cd\u65b0\u957f\u51fa\u4e00\u68f5\u690d\u682a\uff0c\u4e5f\u5373\u5df2\u7ecf\u5206\u5316\u7684\u830e\u7ec6\u80de\u53ef\u4ee5\u6539\u53d8\u547d
\n\u8fd0\u5206\u5316\u51fa\u65b0\u7684\u6839\u830e\u53f6\u7ec6\u80de\u3002\u800c\u65e9\u57281962\u5e74\uff0c\u4e5f\u5373Shinya\u51fa\u751f\u7684\u90a3\u4e00\u5e74\uff0c\u82f1\u56fd\u7684
\nJohn Gurdon\u7235\u58eb\uff08\u4e0eShinya\u5171\u4eab\u8bfa\u8d1d\u5c14\u5956\uff09\u62a5\u9053\u4e86\u4ed6\u7684\u60ca\u4eba\u53d1\u73b0\uff1a\u628a\u874c\u86aa\u7684\u80a0
\n\u7ec6\u80de\u6838\u79fb\u690d\u5230\u53bb\u6838\u7684\u86d9\u5375\u4e2d\uff0c\u65b0\u7ec6\u80de\u53ef\u4ee5\u53d1\u80b2\u81f3\u874c\u86aa\u9636\u6bb5[7]\u3002\u5982\u679c\u628a\u6742\u5408\u7ec6\u80de
\n\u53d1\u80b2\u5230\u56ca\u80da\u671f\uff0c\u7528\u56ca\u80da\u671f\u7684\u7ec6\u80de\u6838\u518d\u505a\u4e00\u6b21\u6838\u79fb\u690d\uff0c\u90a3\u4e48\u5c31\u53ef\u4ee5\u53d1\u80b2\u51fa\u53ef\u751f\u80b2\u4f20
\n\u4ee3\u7684\u6210\u86d9[8]\u3002\u8fdb\u4e00\u6b65\u5730\uff0c\u4e3a\u4e86\u8bf4\u670d\u4eba\u4eec\u63a5\u53d7\u7ec8\u672b\u5206\u5316\u7684\u7ec6\u80de\u6838\u4e5f\u5177\u6709\u591a\u80fd\u6027\uff0c
\n\u4ed6\u628a\u6210\u86d9\u4e0d\u540c\u7ec4\u7ec7\u7684\u7ec6\u80de\u8fdb\u884c\u4f53\u5916\u57f9\u517b\uff0c\u53d1\u73b0\u6838\u79fb\u690d\u540e\u6765\u6e90\u4e0d\u540c\u7684\u6742\u5408\u7ec6\u80de\u90fd\u53ef
\n\u4ee5\u53d1\u80b2\u5230\u874c\u86aa\u9636\u6bb5[9]\u30021997\u5e74\uff0cIan Wilmut\u548cKeith Campbell\u57fa\u4e8e\u540c\u6837\u7684\u539f\u7406\uff0c
\n\u628a\u7f8a\u7684\u4e73\u817a\u7ec6\u80de\u6838\u79fb\u690d\u5230\u53bb\u6838\u7684\u7f8a\u5375\u4e2d\uff0c\u6210\u529f\u5730\u57f9\u80b2\u51fa\u4e86\u514b\u9686\u7f8a\u591a\u8389[10]\u30022001
\n\u5e74\uff0c\u65e5\u672c\u79d1\u5b66\u5bb6\u53d1\u73b0\uff0c\u901a\u8fc7\u4e0e\u5e72\u7ec6\u80de\u878d\u5408\uff0c\u80f8\u817a\u7ec6\u80de\u6838\u83b7\u5f97\u4e86\u5f88\u5927\u7a0b\u5ea6\u7684\u91cd\u7f16\u7a0b
\n[11]\u3002<\/p>\n
\u3000\u3000Shinya\u8ba1\u5212\u7684\u7b2c\u4e00\u6b65\u662f\u627e\u5230\u5c3d\u53ef\u80fd\u591a\u7684\uff0c\u7c7b\u4f3c\u4e8eNat1\u53c2\u4e0e\u7ef4\u6301\u5e72\u7ec6\u80de\u529f\u80fd\u7684
\n\u56e0\u5b50\uff08\u7ef4\u6301\u56e0\u5b50\u7684\u610f\u601d\u662f\u8fd9\u4e9b\u56e0\u5b50\u662f\u80da\u80ce\u5e72\u7ec6\u80de\u5728\u4f53\u5916\u57f9\u517b\u7ef4\u6301\u591a\u80fd\u6027\u6240\u5fc5\u9700
\n\u7684\uff09\u3002\u4ed6\u5927\u80c6\u63a8\u6d4b\uff0c\u5728\u5206\u5316\u7684\u7ec6\u80de\u4e2d\u8fc7\u8868\u8fbe\u8fd9\u4e9b\u7ef4\u6301\u56e0\u5b50\u4e5f\u8bb8\u53ef\u4ee5\u8ba9\u5b83\u53d8\u56de\u591a\u80fd
\n\u5e72\u7ec6\u80de\u3002\u4e00\u65e6\u6210\u529f\uff0c\u8bf1\u5bfc\u7684\u591a\u80fd\u5e72\u7ec6\u80de\u4f1a\u6709\u7740\u80da\u80ce\u5e72\u7ec6\u80de\u6240\u4e0d\u5177\u5907\u7684\u4f18\u52bf\uff1a\u5b83\u4e0d
\n\u4ec5\u53ef\u4ee5\u7ed5\u5f00\u80da\u80ce\u5e72\u7ec6\u80de\u5f15\u8d77\u7684\u4f26\u7406\u95ee\u9898\uff0c\u75c5\u4eba\u672c\u8eab\u7684\u8bf1\u5bfc\u5e72\u7ec6\u80de\u6539\u9020\u540e\u91cd\u65b0\u690d\u5165
\n\u75c5\u4eba\u65f6\uff0c\u7531\u4e8e\u662f\u81ea\u8eab\u7684\u7ec6\u80de\uff0c\u5c06\u4e0d\u4f1a\u6709\u514d\u75ab\u6392\u65a5\u7684\u96be\u9898\u3002<\/p>\n
\u3000\u3000\u5728\u8fd9\u4e2a\u8fdc\u5927\u524d\u666f\u7684\u611f\u53ec\u4e0b\uff0cShinya\u679c\u7136\u201c\u5ffd\u60a0\u201d\u4e86\u4e09\u4e2a\u5b66\u751f\u52a0\u5165\u4ed6\u5b9e\u9a8c\u5ba4\u3002
\n\u5f88\u5feb\u5730\uff0c\u4ed6\u4eec\u9274\u5b9a\u51fa\u4e00\u7cfb\u5217\u7684\u5728\u80da\u80ce\u5e72\u7ec6\u80de\u7279\u5f02\u8868\u8fbe\u7684\u57fa\u56e0\u3002\u5176\u4e2d\u4e00\u4e2a\u57fa\u56e0\u5c31\u662f
\nFbx15\u3002Shinya\u7684\u5b66\u751fYoshimi Tokuzawa\u53d1\u73b0Fbx15\u9664\u4e86\u7279\u5f02\u8868\u8fbe\u4e8e\u80da\u80ce\u5e72\u7ec6\u80de\u5916\uff0c
\n\u5b83\u8fd8\u80fd\u88ab\u53e6\u5916\u4e24\u4e2a\u80da\u80ce\u5e72\u7ec6\u80de\u7ef4\u6301\u56e0\u5b50Oct3\/4\u548cSox2\u76f4\u63a5\u8c03\u63a7\u3002Shinya\u8ddf
\nYoshimi\u8bf4\uff1aFbx15\u5e94\u8be5\u53c2\u4e0e\u7ef4\u6301\u5e72\u7ec6\u80de\u591a\u80fd\u6027\u548c\u80da\u80ce\u7684\u53d1\u80b2\uff0c\u6211\u731c\u4f60\u6ca1\u6709\u529e\u6cd5\u5f97
\n\u5230Fbx15\u6572\u9664\u7684\u7eaf\u5408\u9f20\u3002Yoshimi\u6784\u5efa\u8d28\u7c92\u505a\u4e86\u57fa\u56e0\u6572\u9664\u5c0f\u9f20\uff0c\u628a\u67d3\u8272\u4f53\u4e0a\u7684
\nFbx15\u57fa\u56e0\u901a\u8fc7\u540c\u6e90\u91cd\u7ec4\u66ff\u6362\u6210\u6297G418\u836f\u7269\u7684\u57fa\u56e0neo\u3002<\/p>\n
\u3000\u3000\u590d\u6742\u7684\u751f\u547d\u53c8\u4e00\u6b21\u611a\u5f04\u4e86Shinya\uff1aFbx15\u6572\u9664\u7684\u7eaf\u5408\u9f20\u6d3b\u5f97\u5f88\u5065\u5eb7\uff0c\u6ca1\u6709\u663e
\n\u89c1\u7684\u8868\u578b\u3002Shinya\u53c8\u6311\u6218\u4ed6\u7684\u5b66\u751f\u8bf4\uff1a\u597d\u5427\uff0cFbx15\u4e5f\u8bb8\u4e0d\u662f\u5c0f\u9f20\u80da\u80ce\u53d1\u80b2\u6240\u5fc5
\n\u9700\u7684\uff0c\u4f46\u662f\u5b83\u5e94\u8be5\u662f\u7ef4\u6301\u4f53\u5916\u80da\u80ce\u5e72\u7ec6\u80de\u6240\u5fc5\u9700\u7684\uff0c\u6211\u6253\u8d4c\u4f60\u6ca1\u6709\u529e\u6cd5\u5728\u80da\u80ce\u5e72
\n\u7ec6\u80de\u4e2d\u5f7b\u5e95\u6572\u9664\u8fd9\u4e2a\u57fa\u56e0\u3002\u52e4\u5feb\u7684Yoshimi\u4e8e\u662f\u7528\u8f83\u9ad8\u6d53\u5ea6\u7684G418\u4ece\u5e72\u7ec6\u80de\u4e2d\u7b5b
\n\u5230\u4e86\u7eaf\u5408\u7684\u6572\u9664\u682a\uff0c\u8fd8\u662f\u6d3b\u5f97\u597d\u597d\u7684\uff0c\u6ca1\u6709\u8868\u578b[12]\u3002Shinya\u540e\u6765\u5728\u56de\u5fc6\u7684\u65f6\u5019
\n\u6253\u8da3\u5230\uff1a\u5c0f\u9f20\u5f88happy\uff0c\u7ec6\u80de\u4e5f\u5f88happy\uff0c\u552f\u4e00\u4e0dhappy\u7684\u5c31\u662f\u53ef\u601c\u7684\u5b66\u751fYoshimi
\n\u4e86\u3002<\/p>\n
\u3000\u3000\u4f46\u662f\u82b1\u8fd9\u4e48\u591a\u7cbe\u529b\u505a\u7684\u6572\u9664\u5c0f\u9f20\u4e0d\u80fd\u5c31\u8fd9\u4e48\u7b97\u4e86\u5427\u3002Shinya\u53c8\u4e00\u6b21\u5f00\u52a8\u8111\u7b4b\uff0c
\n\u60f3\u8981\u5e9f\u7269\u5229\u7528\u3002\u4ed6\u53d1\u73b0\u7531\u4e8eFbx15\u53ea\u5728\u80da\u80ce\u5e72\u7ec6\u80de\u8868\u8fbe\uff0cFbx15 promoter\u64cd\u63a7\u7684
\n\u6297\u836f\u57fa\u56e0neo\u5728\u6210\u4f53\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de\u91cc\u4e0d\u8868\u8fbe\uff0c\u6240\u4ee5\u7ec6\u80de\u5728\u836f\u7269G418\u5904\u7406\u4e0b\u4f1a\u6b7b\u4ea1\uff1b
\n\u800c\u6572\u9664\u9f20\u91cc\u5f97\u5230\u7684\u80da\u80ce\u5e72\u7ec6\u80de\u5374\u53ef\u4ee5\u5728\u5f88\u9ad8\u6d53\u5ea6\u7684G418\u4e2d\u751f\u957f\u3002\u5982\u679c\u6210\u7ea4\u7ef4\u7ec6\u80de
\n\u80fd\u901a\u8fc7\u67d0\u79cd\u56e0\u5b50\u8bf1\u5bfc\u6210\u591a\u80fd\u5e72\u7ec6\u80de\uff0c\u90a3\u4e48\u5b83\u5c31\u4f1a\u4ea7\u751f\u5bf9G418\u7684\u6297\u836f\u6027\u3002\u5373\u4fbf\u6210\u7ea4
\n\u7ef4\u7ec6\u80de\u53ea\u662f\u83b7\u5f97\u4e86\u90e8\u5206\u80da\u80ce\u5e72\u7ec6\u80de\u7684\u7279\u6027\uff0c\u90a3\u4e48\u5b83\u4e5f\u5e94\u8be5\u80fd\u6297\u4f4e\u6d53\u5ea6\u7684G418\u3002
\nFbx15\u6572\u9664\u9f20\u5b9e\u9645\u4e0a\u63d0\u4f9b\u4e86\u5f88\u597d\u7684\u7b5b\u9009\u8bf1\u5bfc\u5e72\u7ec6\u80de\u7684\u7cfb\u7edf\uff01<\/p>\n
\u3000\u3000\u4eac\u90fd\u5927\u5b66\u7684\u5316\u86f9\u6210\u8776\u9636\u6bb5-iPS<\/p>\n
\u3000\u3000\u51ed\u501f\u4ed6\u9274\u5b9a\u80da\u80ce\u5e72\u7ec6\u80de\u7ef4\u6301\u56e0\u5b50\u7684\u51fa\u8272\u5de5\u4f5c\uff0c2004\u5e74Shinya\u5728\u540d\u6c14\u66f4\u5927\u7684\u4eac
\n\u90fd\u5927\u5b66\u627e\u5230\u4e86\u65b0\u7684\u804c\u4f4d\u3002\u9664\u4e86Fbx15\u6572\u9664\u9f20\u7684\u7b5b\u9009\u7cfb\u7edf\uff0cShinya\u8fd8\u79ef\u7d2f\u4e86\u4ed6\u9274\u5b9a
\n\u7684\u52a0\u4e0a\u6587\u732e\u62a5\u9053\u768424\u4e2a\u5019\u9009\u7ef4\u6301\u56e0\u5b50\u3002Shinya\u8dc3\u8dc3\u6b32\u8bd5\uff0c\u4ed6\u51c6\u5907\u7834\u58f3\u800c\u51fa\uff0c\u62cd\u7fc5
\n\u6210\u8776\u4e86\uff01<\/p>\n
\u3000\u3000Shinya\u7684\u53e6\u4e00\u4f4d\u5b66\u751fKazutoshi Takahashi\u6b64\u524d\u5df2\u7ecf\u53d1\u8868\u4e86\u4e00\u7bc7\u5173\u4e8e\u5e72\u7ec6\u80de
\n\u81f4\u764c\u6027\u7684Nature\u6587\u7ae0\u3002Shinya\u51b3\u610f\u8ba9\u4ed6\u6765\u627f\u62c5\u6700\u5927\u80c6\u7684\u8bfe\u9898-\u9006\u5206\u5316\u6210\u4f53\u7ec6\u80de\uff0c
\n\u56e0\u4e3a\u4ed6\u77e5\u9053\uff0c\u6709\u4e00\u7bc7Nature\u6587\u7ae0\u4fdd\u5e95\uff0c\u5373\u4fbf\u63a5\u4e0b\u6765\u7684\u51e0\u5e74\u4e00\u65e0\u6240\u83b7\uff0c\u4ed6\u7684\u5b66\u751f\u4e5f
\n\u80fd\u627f\u53d7\u5f97\u4e86\u3002<\/p>\n
\u3000\u3000\u5373\u4fbf\u6709\u5f88\u597d\u7684\u7b5b\u9009\u7cfb\u7edf\uff0c\u8fd9\u4e2a\u8bfe\u9898\u5728\u5f53\u521d\u770b\u6765\u4e5f\u662f\u975e\u5e38\u5192\u9669\u751a\u81f3\u662f\u4e0d\u53ef\u884c\u7684\u3002
\n\u5f53\u65f6\u7684\u4eba\u4eec\u666e\u904d\u8ba4\u4e3a\u6210\u4f53\u7ec6\u80de\u5931\u53bb\u4e86\u591a\u80fd\u6027\uff0c\u4e5f\u8bb8\u6210\u4f53\u7ec6\u80de\u672c\u8eab\u5c31\u662f\u4e0d\u53ef\u9006\u8f6c\u7684\uff0c
\n\u4f60\u505a\u4ec0\u4e48\u4e5f\u6ca1\u6709\u7528\u3002\u5373\u4fbf\u901a\u8fc7\u8f6c\u6838\u6280\u672f\u5b9e\u73b0\u4e86\u6210\u4f53\u7ec6\u80de\u6838\u547d\u8fd0\u7684\u9006\u8f6c\uff0c\u90a3\u4e5f\u53ea\u662f
\n\u7ec6\u80de\u6838\uff0c\u4e0d\u662f\u6574\u4e2a\u7ec6\u80de\u3002\u80da\u80ce\u7ec6\u80de\u548c\u6210\u4f53\u7ec6\u80de\u7684\u67d3\u8272\u4f53\u662f\u4e00\u6837\u7684\uff0c\u7ec6\u80de\u6838\u5177\u6709\u5168
\n\u80fd\u6027\uff0c\u5c1a\u53ef\u7406\u89e3\u3002\u800c\u4e14\u8981\u5b9e\u73b0\u7ec6\u80de\u6838\u7684\u9006\u8f6c\u8fd8\u9700\u8981\u628a\u6838\u8f6c\u5230\u5375\u7ec6\u80de\u4e2d\uff0c\u8ba9\u5375\u7ec6\u80de
\n\u8d28\u5e2e\u52a9\u5b83\u91cd\u7f16\u7a0b\uff0c\u800c\u5375\u7ec6\u80de\u8d28\u4e2d\u7684\u86cb\u767d\u4e0d\u8ba1\u5176\u6570\u3002\u5982\u679c\u8981\u5b9e\u73b0\u6574\u4e2a\u7ec6\u80de\u547d\u8fd0\u7684\u9006
\n\u8f6c\u9700\u8981\u8ba9\u7ec6\u80de\u8d28\u4e2d\u6240\u6709\u7684\u86cb\u767d\u91cd\u65b0\u6d17\u724c\u3002\u5373\u4fbf\u7ec6\u80de\u53ef\u4ee5\u91cd\u65b0\u7f16\u7a0b\uff0c\u90a3\u4e5f\u5e94\u8be5\u662f\u5f88
\n\u591a\u86cb\u767d\u5171\u540c\u53c2\u4e0e\u7684\u3002Shinya\u5f53\u5e74\u5728\u624b\u4e0a\u7684\u4ec5\u4ec5\u662f24\u4e2a\u56e0\u5b50\u3002\u4e5f\u8bb8\u6709\u53e6\u5916\u51e0\u767e\u51e0\u5343
\n\u79cd\u56e0\u5b50\u88ab\u9057\u6f0f\uff0c\u7f3a\u5c11\u5176\u4e2d\u4e00\u79cd\u90fd\u65e0\u6cd5\u5b9e\u73b0\u91cd\u7f16\u7a0b\u3002\u7528\u8fd924\u4e2a\u56e0\u5b50\u5f02\u60f3\u5929\u5f00\u8981\u5b9e\u73b0
\n\u7ec6\u80de\u547d\u8fd0\u7684\u9006\u8f6c\uff0c\u6839\u636e\u5df2\u6709\u7684\u77e5\u8bc6\u4ece\u903b\u8f91\u4e0a\u8bb2\u53ef\u80fd\u6027\u51e0\u4e4e\u4e3a\u96f6\u3002<\/p>\n
\u3000\u3000Kazutoshi\u8fd9\u4e2a\u6123\u5934\u9752\u4e0d\u7ba1\u8fd9\u4e9b\uff0c\u4ed6\u7ed9\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e00\u4e00\u611f\u67d3\u8fc7\u8868\u8fbe\u8fd9\u4e9b\u56e0\u5b50
\n\u7684\u75c5\u6bd2\uff0c\u7ed3\u679c\u5f53\u7136\u6ca1\u6709\u7b5b\u9009\u5230\u4efb\u4f55\u6297G418\u7684\u7ec6\u80de\u3002Shinya\u77e5\u9053\u5982\u4f55\u4fdd\u6301\u5b66\u751f\u7684\u6597
\n\u5fd7\uff0c\u4ed6\u6545\u4f5c\u9547\u5b9a\u5730\u8bf4\uff1a\u4f60\u770b\uff0c\u8fd9\u8bf4\u660e\u6211\u4eec\u7684\u7b5b\u9009\u7cfb\u7edf\u5f88\u597d\u554a\uff0c\u6ca1\u6709\u51fa\u73b0\u4efb\u4f55\u5047\u9633
\n\u6027\u3002<\/p>\n
\u3000\u3000\u5728\u8bd5\u4e86\u4e00\u904d\u65e0\u679c\u540e\uff0cKazutoshi\u5927\u80c6\u63d0\u51fa\u60f3\u628a24\u4e2a\u75c5\u6bd2\u6df7\u5408\u8d77\u6765\u540c\u65f6\u611f\u67d3\u7ec6
\n\u80de\u3002Shinya\u89c9\u5f97\u8fd9\u662f\u5f88\u611a\u8822\u7684\u60f3\u6cd5\uff1a\u6ca1\u4eba\u8fd9\u4e48\u5e72\u8fc7\u554a\u540c\u5b66\uff0c\u4e0d\u8fc7\u6b7b\u9a6c\u5f53\u4f5c\u6d3b\u9a6c\u533b\uff0c
\n\u4f60\u4e0d\u5acc\u7d2f\u7684\u8bdd\u5c31\u53bb\u8bd5\u5427\u3002<\/p>\n
\u3000\u3000\u7b49\u4e86\u51e0\u5929\uff0c\u5947\u8ff9\u7adf\u7136\u53d1\u751f\u4e86\u3002\u57f9\u517b\u677f\u4e0a\u7a00\u7a00\u758f\u758f\u5730\u7adf\u7136\u51fa\u73b0\u4e86\u5341\u51e0\u4e2a\u6297G418
\n\u7684\u7ec6\u80de\u514b\u9686\uff01\u4e00\u4e2a\u5212\u65f6\u4ee3\u7684\u53d1\u73b0\u8bde\u751f\u4e86\u3002<\/p>\n
\u3000\u3000\u5173\u952e\u5b9e\u9a8c\u53d6\u5f97\u7a81\u7834\u4ee5\u540e\uff0c\u5176\u540e\u7684\u4e8b\u60c5\u5c31\u6309\u90e8\u5c31\u73ed\u4e86\u3002Kazutoshi\u6bcf\u6b21\u53bb\u6389\u4e00
\n\u4e2a\u75c5\u6bd2\uff0c\u628a\u5269\u4e0b\u768423\u4e2a\u75c5\u6bd2\u6df7\u5408\u611f\u67d3\u6210\u4f53\u7ec6\u80de\uff0c\u770b\u80fd\u957f\u591a\u5c11\u514b\u9686\uff0c\u4ee5\u6b64\u6765\u9274\u522b\u54ea
\n\u4e00\u4e9b\u56e0\u5b50\u662f\u8bf1\u5bfc\u5e72\u7ec6\u80de\u6240\u5fc5\u9700\u7684\u3002\u6700\u540e\u4ed6\u9274\u5b9a\u51fa\u4e86\u56db\u4e2a\u660e\u661f\u56e0\u5b50\uff1aOct3\/4\uff0cSox2\uff0c
\nc-Myc\u548cKlf4\u3002\u8fd9\u56db\u4e2a\u56e0\u5b50\u5728\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u8fc7\u8868\u8fbe\uff0c\u5c31\u8db3\u4ee5\u628a\u5b83\u9006\u8f6c\u4e3a\u591a\u80fd\u5e72\u7ec6
\n\u80de\uff01<\/p>\n
\u3000\u3000\u90a3\u6297G418\u7684\u7ec6\u80de\u514b\u9686\u5c31\u4e00\u5b9a\u662f\u591a\u80fd\u5e72\u7ec6\u80de\u5417\uff1f\u4ed6\u4eec\u901a\u8fc7\u4e00\u7cfb\u5217\u7684\u6307\u6807\uff0c\u6bd4\u5982
\n\u57fa\u56e0\u8868\u8fbe\u8c31\uff0c\u5206\u5316\u6f5c\u80fd\u7b49\uff0c\u53d1\u73b0\u8fd9\u4e9b\u7ec6\u80de\u5728\u76f8\u5f53\u5927\u7684\u7a0b\u5ea6\u4e0a\u4e0e\u80da\u80ce\u5e72\u7ec6\u80de\u76f8\u4f3c\u3002<\/p>\n
\u3000\u30002006\u5e74Shinya\u62a5\u9053\u4e86\u5c0f\u9f20\u8bf1\u5bfc\u5e72\u7ec6\u80de\uff0c\u5f15\u8d77\u79d1\u5b66\u754c\u8f70\u52a8[13]\uff1b2007\u5e74\uff0c\u4ed6\u5728
\n\u4eba\u7684\u7ec6\u80de\u4e2d\u540c\u6837\u5b9e\u73b0\u4e86\u7ec6\u80de\u547d\u8fd0\u7684\u9006\u8f6c\uff0c\u79d1\u5b66\u754c\u6cb8\u817e\u4e86[14]\u3002<\/p>\n
\u3000\u3000\u5c55\u671b<\/p>\n
\u3000\u3000\u56de\u8fc7\u5934\u6765\uff0c\u79cd\u79cd\u4e0d\u53ef\u80fd\uff0cShinya\u600e\u4e48\u5c31\u6210\u529f\u4e86\u5462\uff1f\u73b0\u5728\u901a\u8fc7\u66f4\u591a\u7684\u7814\u7a76\uff0c\u6211
\n\u4eec\u77e5\u9053\uff0c\u5e72\u7ec6\u80de\u7279\u6027\u7684\u7ef4\u6301\u662f\u7531\u4e00\u4e2a\u57fa\u56e0\u7f51\u7edc\u6765\u5171\u540c\u4f5c\u7528\u7684\uff0c\u901a\u8fc7\u4e0a\u8c03\u67d0\u4e9b\u5173\u952e
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\n\u662f\u5fc5\u987b\u7684\uff0c\u7528\u8fd9\u56db\u4e2a\u56e0\u5b50\u4ee5\u5916\u7684\u5176\u5b83\u56e0\u5b50\u8fdb\u884c\u7ec4\u5408\u53ef\u4ee5\u8fbe\u5230\u540c\u6837\u7684\u76ee\u7684\u3002\u8fd9\u597d\u6bd4
\n\u662f\u4e00\u5f20\u5927\u7f51\uff0c\u4f60\u53ea\u8981\u80fd\u6491\u8d77\u5176\u4e2d\u7684\u51e0\u4e2a\u652f\u70b9\uff0c\u5c31\u53ef\u4ee5\u628a\u6574\u5f20\u7f51\u6491\u8d77\u6765\u3002\u5f53\u7136\uff0c
\nShinya\u7684\u6210\u529f\u4e5f\u6709\u76f8\u5f53\u5927\u7684\u4fa5\u5e78\u6210\u5206\uff0c\u5047\u8bbe\u5728\u4ed6\u768424\u4e2a\u5019\u9009\u56e0\u5b50\u4e2d\u7f3a\u4e86\u8fd9\u56db\u4e2a\u660e
\n\u661f\u5206\u5b50\u4e2d\u7684\u4e00\u4e2a\uff0c\u90a3\u4e48\u4ed6\u65e0\u8bba\u600e\u4e48\u52aa\u529b\u4e5f\u6ca1\u6709\u529e\u6cd5\u5f97\u5230iPS\u3002<\/p>\n
\u3000\u3000iPS\u7684\u53d1\u73b0\u6709\u7740\u4e0d\u540c\u5bfb\u5e38\u7684\u610f\u4e49\u3002\u9996\u5148\uff0c\u5b83\u66f4\u65b0\u4e86\u4eba\u4eec\u7684\u89c2\u5ff5\uff0c\u4ece\u6b64\u4e4b\u540e\u4eba
\n\u4eec\u4e0d\u518d\u8ba4\u4e3a\u7ec6\u80de\u7684\u547d\u8fd0\u4e0d\u53ef\u9006\u8f6c\uff0c\u4e0d\u5355\u53ef\u4ee5\u9006\u8f6c\uff0c\u7ec6\u80de\u5176\u5b9e\u8fd8\u53ef\u4ee5\u5b9e\u73b0\u4e0d\u540c\u7ec4\u7ec7
\n\u95f4\u7684\u8f6c\u5206\u5316\uff08Transdifferentiation\uff09\u3002\u5176\u6b21\uff0ciPS\u7ec6\u80de\u7ed5\u8fc7\u4e86\u80da\u80ce\u5e72\u7ec6\u80de\u7684\u4f26
\n\u7406\u56f0\u5883\uff0c\u5f88\u591a\u5b9e\u9a8c\u5ba4\u90fd\u53ef\u4ee5\u91cd\u590d\u8fd9\u4e2a\u7b80\u5355\u7684\u5b9e\u9a8c\u5f97\u5230iPS\uff0c\u5f00\u5c55\u591a\u80fd\u5e72\u7ec6\u80de\u7684\u7814
\n\u7a76\u3002\u5176\u4e09\uff0ciPS\u7ec6\u80de\u5177\u6709\u5f88\u591a\u80da\u80ce\u5e72\u7ec6\u80de\u6240\u6ca1\u6709\u7684\u4f18\u52bf\uff1a\u6765\u81ea\u4e8e\u75c5\u4eba\u81ea\u8eab\u7684iPS\u7ec6
\n\u80de\u4f53\u5916\u64cd\u4f5c\u540e\u91cd\u65b0\u690d\u5165\u75c5\u4eba\u4f53\u5185\uff0c\u514d\u75ab\u53cd\u5e94\u5c06\u5927\u5927\u51cf\u5c11\uff1b\u5982\u679c\u5c06\u75c5\u4eba\u7684\u4f53\u7ec6\u80de\u9006
\n\u8f6c\u4e3aiPS\u7ec6\u80de\uff0c\u5728\u4f53\u5916\u5206\u5316\u89c2\u5bdf\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\u51fa\u73b0\u7684\u95ee\u9898\uff0c\u5c31\u53ef\u4ee5\u5b9e\u73b0\u5728\u57f9\u517b\u76bf
\n\u91cc\u67d0\u79cd\u7a0b\u5ea6\u4e0a\u6a21\u62df\u75be\u75c5\u7684\u53d1\u751f\uff1b\u75be\u75c5\u7279\u5f02\u7684iPS\u5728\u4f53\u5916\u6269\u589e\u548c\u5206\u5316\u4ee5\u540e\uff0c\u8fd8\u53ef\u4ee5
\n\u7528\u4e8e\u7b5b\u9009\u6cbb\u7597\u8be5\u75be\u75c5\u7684\u836f\u7269\uff0c\u6216\u8005\u5bf9\u836f\u7269\u7684\u6bd2\u6027\u8fdb\u884c\u68c0\u6d4b\u3002<\/p>\n
\u3000\u3000\u4f46\u662f\u8fd9\u4ec5\u4ec5\u662f\u65b0\u7684\u5f00\u59cb\uff0c\u751f\u547d\u79d1\u5b66\u5982\u6b64\u590d\u6742\u548c\u4e0d\u53ef\u9884\u6d4b\uff0c\u8981\u628a\u8fd9\u4e9b\u613f\u666f\u53d8\u6210
\n\u73b0\u5b9e\uff0c\u8ba9iPS\u771f\u6b63\u9020\u798f\u4eba\u7c7b\uff0c\u8fd9\u5176\u4e2d\u8fd8\u6709\u91cd\u91cd\u7684\u56f0\u96be\u3002Shinya Yamanka\uff0c\u8fd9\u4f4d\u79d1
\n\u5b66\u7684\u5ba0\u513f\uff0c\u6000\u7740\u6700\u521d\u5e2e\u52a9\u66f4\u591a\u75c5\u4eba\u7684\u7406\u60f3\uff0c\u65e0\u754f\u5730\u8e0f\u4e0a\u4e86\u65b0\u7684\u5f81\u7a0b\u3002<\/p>\n
\u3000\u3000\u6ce8\u660e\uff1a<\/p>\n
\u3000\u3000\u4f5c\u8005\u672c\u4eba\u5e76\u975e\u7814\u7a76iPS\uff0c\u6240\u4ee5\u51fa\u73b0\u4e00\u4e9b\u9519\u8bef\u5728\u6240\u96be\u514d\uff0c\u6b22\u8fce\u6307\u6b63\u3002<\/p>\n
\u3000\u3000\u672c\u6587\u4e3b\u8981\u53c2\u8003\u4e86Shinya Yamanaka\u5728NIH\u8bb2\u5ea7\uff1a
\nhttps:\/\/videocast.nih.gov\/Summary.asp?File=15547<\/p>\n
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\ncells from adult human fibroblasts by defined factors. Cell 131,
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(XYS20121019)<\/p>\n","protected":false},"excerpt":{"rendered":"
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